Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Igf2  insulin-like growth factor 2   (Synonyms: Igf-2, Igf-II, M6pr, Mpr, Peg2)
Results	Reference
1	J:65001 Constancia M, Dean W, Lopes S, Moore T, Kelsey G, Reik W, Deletion of a silencer element in igf2 results in loss of imprinting independent of H19. Nat Genet. 2000 Oct;26(2):203-6
1*	J:78353 Crossey PA, Pillai CC, Miell JP, Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice. J Clin Invest. 2002 Aug;110(3):411-8
1*	J:75952 Davies K, Bowden L, Smith P, Dean W, Hill D, Furuumi H, Sasaki H, Cattanach B, Reik W, Disruption of mesodermal enhancers for Igf2 in the minute mutant. Development. 2002 Apr;129(7):1657-68
1*	J:20964 Feil R, Walter J, Allen ND, Reik W, Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes. Development. 1994 Oct;120(10):2933-43
1*	J:47421 Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G, Zimmer A, Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome [see comments]. Nat Med. 1998 May;4(5):619-22
1	J:298625 Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gomez G, Constancia M, Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLoS Genet. 2020 Oct;16(10):e1009069
1	J:49355 Hatano N, Eversole-Cire P, Ferguson-Smith AC, Jones PA, Surani MA, Sasaki H, Enhancer-dependent, locus-wide regulation of the imprinted mouse insulin-like growth factor II gene. J Biochem. 1998 May;123(5):984-91
1	J:173610 Ideraabdullah FY, Abramowitz LK, Thorvaldsen JL, Krapp C, Wen SC, Engel N, Bartolomei MS, Novel cis-regulatory function in ICR-mediated imprinted repression of H19. Dev Biol. 2011 Jul 15;355(2):349-57
1	J:63868 Kaffer CR, Srivastava M, Park KY, Ives E, Hsieh S, Batlle J, Grinberg A, Huang SP, Pfeifer K, A transcriptional insulator at the imprinted H19/Igf2 locus. Genes Dev. 2000 Aug 1;14(15):1908-19
1	J:28716 Leighton PA, Saam JR, Ingram RS, Stewart CL, Tilghman SM, An enhancer deletion affects both H19 and Igf2 expression. Genes Dev. 1995 Sep 1;9(17):2079-89
1*	J:91593 Lewis A, Mitsuya K, Constancia M, Reik W, Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region. Mol Cell Biol. 2004 Jul;24(13):5650-6
1	J:94521 Murrell A, Heeson S, Bowden L, Constancia M, Dean W, Kelsey G, Reik W, An intragenic methylated region in the imprinted Igf2 gene augments transcription. EMBO Rep. 2001 Dec;2(12):1101-6
1*	J:21203 Newell S, Ward A, Graham C, Discriminating translation of insulin-like growth factor-II (IGF-II) during mouse embryogenesis. Mol Reprod Dev. 1994 Nov;39(3):249-58
1*	J:224896 Runge S, Nielsen FC, Nielsen J, Lykke-Andersen J, Wewer UM, Christiansen J, H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. J Biol Chem. 2000 Sep 22;275(38):29562-9
1*	J:52214 Walsh CP, Bestor TH, Cytosine methylation and mammalian development. Genes Dev. 1999 Jan 1;13(1):26-34
1*	J:68165 Weber M, Milligan L, Delalbre A, Antoine E, Brunel C, Cathala G, Forne T, Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting. Mech Dev. 2001 Mar;101(1-2):133-41